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CD74 is a kind II transmembrane protein consisting of an N-terminal cytosolic tail, a short transmembrane region, and an extended C-terminus luminal location. Human CD74 is encoded on chromosome five and includes 4 isoforms. Isoforms p33 and p41 are generated by different splicing, which is, the p33 isoform is made by excluding exon 6b from p41 CD74 transcript. Isoforms p35 and p43 originate from another begin internet site (16–21).
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Renal inflammation is an initial pathological system for the duration of progressive renal injury regardless of the First bring about. Macrophage migration inhibitory factor (MIF) is A really proinflammatory tension mediator that is extremely expressed in a number of each inflammatory cells and intrinsic kidney cells. MIF is introduced in the diseased kidney immediately on stimulation to bring about renal inflammation by activating macrophages and T cells, and advertising and marketing the production of proinflammatory cytokines, chemokines, and pressure molecules by way of signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling.
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